Deciphering the biology of IgG4-related disease: specific antigens and disease?
نویسندگان
چکیده
منابع مشابه
Ormond's Disease--IgG4-related Disease.
Ormond's disease is a relatively rare disease with unclear etiology, characterized by chronic periaortitis and retroperitoneal fibrosis. The inflammatory process affects the infrarenal part of the abdominal aorta and the iliac arteries, and the presence of infiltrates encasing the ureters and inferior vena cava. This disease is currently classed as an IgG4-related disease. In our review we anal...
متن کاملExposure to occupational antigens might predispose to IgG4-related disease
IgG4-associated cholangitis (IAC) and autoimmune pancreatitis are the predominant manifestations of IgG4-related diseases (IgG4RD); their pathogenesis is enigmatic. Serum IgG4 concentrations are generally elevated in IgG4-RD but the biological implications thereof have not been explained. IgG4, traditionally regarded as a regulatory antibody, has been consistently reported to be upregulated in ...
متن کاملIgG4-Related Perineural Disease
Aims. To elucidate characteristics of IgG4-related disease involving the peripheral nervous system. Methods. Retrospective review of 106 patients with IgG4-related disease identified 21 peripheral nerve lesions in 7 patients. Clinicopathological and radiological features were examined. Results. Peripheral nerve lesions were commonly identified in orbital or paravertebral area, involving orbital...
متن کاملIgG4-related sclerosing disease.
Based on histological and immunohistochemical examination of various organs of patients with autoimmune pancreatitis (AIP), a novel clinicopathological entity of IgG4-related sclerosing disease has been proposed. This is a systemic disease that is characterized by extensive IgG4-positive plasma cells and T-lymphocyte infiltration of various organs. Clinical manifestations are apparent in the pa...
متن کامل[IgG4-related disease].
IgG4-related disease is a recently recognized systemic syndrome characterized by mass-forming lesions, mainly in exocrine tissue, that consist of lymphoplasmacytic infiltrates and sclerosis. There are numerous IgG4+ plasma cells in the affected tissues, and the serum IgG4 level is elevated in these patients. Ocular adnexal IgG4-related disease frequently involves bilateral lacrimal glands, and ...
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ژورنال
عنوان ژورنال: Gut
سال: 2017
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gutjnl-2017-314861